American cheap flights carrier AirTran Airways has

first_imgAmerican cheap flights carrier AirTran Airways has announced plans to start flights between Columbus, Ohio and Fort Lauderdale from March 5th.It will be the only airline to offer a non-stop daily flight between Port Columbus International Airport and Fort Lauderdale Hollywood International Airport once the service comes into effect.Commenting on the new flights, Kevin Healy, AirTran Airways’ senior vice president of marketing and planning, said: “AirTran Airways has seen a lot of success in Columbus since entering the market in November 2008 and we are dedicated to expanding our operations where additional flights are needed.”The carrier will now offer connecting flights to over 40 destinations across Atlanta in addition to its non-stop routes between Columbus and Atlanta, Orlando, Fort Myers and Fort Lauderdale.AirTran Airways was established in June 1993 and currently flies to 57 destinations in the US.It is based at Hartsfield-Jackson Atlanta International Airport and is the world’s biggest Boeing 717 operator. ReturnOne wayMulti-cityFromAdd nearby airports ToAdd nearby airportsDepart14/08/2019Return21/08/2019Cabin Class & Travellers1 adult, EconomyDirect flights onlySearch flights Map RelatedAirTran Airways launches new flight to CancunAirTran Airways has launched a daily flight to Cancun International Airport from Baltimore.AirTran Airways to introduce flights to Fort LauderdaleThe non-stop service will come into effect on November 4th, the same date the airline reinstates flights to Fort Myers.AirTran to launch new flight between Atlanta and BransonAirTran to launch new flight between Atlanta and Bransonlast_img read more

Rep Muxlow announces February office hours

first_img Categories: News Tags: #SB 05Feb Rep. Muxlow announces February office hourscenter_img State Rep. Paul Muxlow of Brown City announced House District 83 office hours for the month of February for residents of Sanilac County, Burtchville Township, Fort Gratiot Township and the city of Port Huron.Muxlow is hosting two meet-and-greet sessions next week: Feb. 9 in Port Huron and Feb. 13 in Port Sanilac.On Monday, Feb. 9, the lawmaker will be at the Blue Water Chamber of Commerce, 512 McMorran Blvd. in Port Huron, from 3:30 to 4:30 p.m.On Friday, Feb. 13, he will be at Bark Shanty Community Center, 135 Church St. in Port Sanilac, from 11:30 a.m. to 12:30 p.m.“I enjoy meeting with citizens and listening to their suggestions and concerns,” Muxlow said. “It is very important to keep in constant communication with residents so that I can properly represent them in the House.”No appointment is necessary. Those unable to attend may contact Rep. Muxlow at (517) 373-0835 or via email at PaulMuxlow@house.mi.gov.#####About Rep. Muxlow:State Rep. Paul Muxlow is a second-term lawmaker representing the 83rd House District. The 83rd District includes Burtchville Township, Fort Gratiot Township, Port Huron city and Sanilac County. Muxlow can be reached at (517) 373-0835, via email at PaulMuxlow@house.mi.gov or on his website at www.reppaulmuxlow.com. For additional updates follow House Republicans on Facebook and Twitter.last_img read more

Justins note Beyond Meat BYND is soaring The

first_imgJustin’s note: Beyond Meat (BYND) is soaring.The plant-based meat producer is up around 500% since the company went public in May. The company is now worth over $9 billion, and is trading at more than 80 times its trailing 12-month sales.That’s an absurd valuation. But many believe the stock could keep running. That’s because the company is supposed to radically change how people eat.Personally, I think BYND’s a bubble that will pop any day now. But I was interested in the big trend here of plant-based meat. So, I got Doug Casey on the phone to see what he thinks about BYND and the future of food…Justin: Doug, there’s a lot of hype around Beyond Meat right now, and for good reason.Its stock is up around 500% since the company went public in May. Not only that, Whole Foods’ CEO recently described Beyond Meat as the future of food, saying, “You have a business here that is real and that is in the early innings.”Do you buy that? Is plant-based meat really the future?Doug: This trend – and I think it is a trend – has been predicted for some time. When I was in high school, Mr. Blue by Myles Connolly was a popular book for a while. I just looked it up – it was written in 1928. It’s been a long time since I read it, but if my memory serves, among other things it posited that people and machines would both run on the same fuel, a petroleum derivative, in a dystopian future. It’s not an unreasonable prediction. Because although there are 92 naturally occurring elements most food consists of carbon, hydrogen, nitrogen, and oxygen. These elements basically compose all carbohydrates, proteins, and fats. Plus traces of others like iron, copper, and sulfur.Fabricating “food,” or at least something that can fuel the body’s cells, is just practical chemistry. As technology improves it will be possible to create all sorts of foods that look and taste like the real thing. Perhaps better. Science fiction has always been the best predictor of the future, and I have no doubt that “replicators,” like those on Star Trek, will create food. 3-D printing is a major step in that direction.Right now it’s still at the stage of using plants to transform raw materials into something that tastes like meat. The next question is not just whether we can cut out animals, which transform plants. But cut out the plants, which transform raw chemical compounds. It’s only logical that this trend will accelerate. The question is whether the foods are also economic and tasty. Let’s hope it goes in that direction, rather than towards Soylent Green – which is rather unaesthetic. The creation of foods out of various stages of raw material has lots of implications on political and sociological – not to mention philosophical – levels. But we’re mainly interested on how to turn a buck here…As far as making money is concerned, I don’t like to invest in science projects. There’s just too much research and development (R&D), experimentation, and uncertainty – it might even be riskier than mining exploration, which is saying something. In addition, projects like this tend to be cultural problems. And it takes generations to change cultures. So, I wouldn’t touch Beyond Meat’s stock with a cattle prod at the moment.Justin: Why do you think its stock is up so much then?Doug: Well, since I haven’t personally tried any of their products, I can’t comment on their taste or cost. When I do, perhaps I’ll change my opinion. I have no doubt that as the tech improves – which it will – both will get better. But there’s plenty of time to get involved – when other companies are out there, and there’s not a speculative bubble.I think the stock’s gone up because interest rates are near record lows and the Federal Reserve is printing money. All that money has got to go somewhere. It’s just part of the great financial bubble. And it’s generally a bad idea to chase after every fashionable idea. Especially late in a bubble.As far as artificial meat itself is concerned, the Chinese have made many great meat substitutes from mushrooms, soy, and wheat for many decades. When I used to live in Hong Kong, one of my favorite restaurants specialized in Buddhist vegetarian dishes. The menu had lots of pork and beef taste-alikes that were extremely appetizing. I certainly didn’t feel the need for real meat when I ate there. But those products never really made it in the U.S.But I don’t doubt “faux flesh” is a growing trend.Justin: What about the green movement? I imagine eco-conscious millennials have played a huge role in bidding up Beyond Meat’s stock.Doug: This is absolutely part of the green movement. A lot of it is based on people being made to feel guilty for even existing, not to mention eating animals.I understand the ethical argument. I don’t like killing other creatures. I feel somewhat sheepish going to a store and buying meat products that someone else has killed, despite the fact it’s just a question of specialization and division of labor. It’s certainly more authentic to eat what you’ve actually hunted and killed yourself. But that’s impractical in today’s world.This is mostly a matter of economics. Most food is based on corn, soybeans, wheat, and rice. All these commodity groups are grown in gigantic monocultures that cover hundreds of thousands of square miles. Any large artificial monoculture is an accident waiting to happen.The day of the self-sustaining family farm, like the one Joel Salatin runs and writes about, is done. At least for 98% of humanity. I’m not a dedicated farmer like Joel. But I can tell you that at current prices it’s somewhere between hard and impossible to make money growing food at today’s prices.My main objection to faux foods is personal, and aesthetic. I don’t like the idea of eating manufactured or industrial foods. But perhaps that’s just because I have enough money to allow me to eat whatever I want. Those big four grains are for feeding the masses. Humans didn’t eat that kind of food for the first 99% of our existence.That sounds elitist, I know. Which is a bit of a contradiction, because it’s well-known I generally despise today’s “elite.” But, on the other hand, every human who’s not a useless mouth should strive to become elite. It’s just a question of how we define that word. And what you do to become elite. Just being no more than a carbon-based life form that has to be fed doesn’t cut it.If you’re at a certain economic level – as I presume anyone reading this is – you’re not directly affected by whether the corn crop fails, or wheat goes back to $10 a bushel. That’s largely a problem for Third World countries with socialist governments, places where they can’t produce anything but more poor people. But, in that context I’ve got to point out that all the foods, not just wheat, corn, and soybeans, but also cattle, sugar, coffee and orange juice, are at just about historic lows. So, now is the time to get into these things from a speculative point of view.It’s very dangerous to grow anything in a gigantic monoculture. There are viruses, bacteria, insects, and other pests that can wipe out these crops wholesale. The Chinese are dealing with that now with their hog crop; an African swine fever breakout has wiped out 20% to 30% of the hogs in China. Closer to home, flooding in the Midwest has devastated this year’s corn, wheat, and soybean harvests. At the same time that most of the world’s crops have been engineered to be grown using the pesticide glyphosate (RoundUp), there are huge lawsuits being won that could ban its use. It’s accused – quite possibly correctly – as being a dangerous carcinogen. “Roundup Ready” crops don’t do well, however, without RoundUp.I say that with the understanding that productivity of all foods has been going up for many years. Farmers produce two to three times per acre more than they did just fifty years ago. I’m sure, for many reasons not germane to this short discussion, that trend is going to continue. Always remember that the longest bear market in history is commodities. In real terms they’ve been collapsing in price for roughly 10,000 years – punctuated by explosive rallies, usually caused by either natural disasters like flood or drought, or anthropogenic ones, like war and collectivism.My guess is that we’re at the bottom for commodity prices here. Unless we have a credit collapse, there will be fortunes made in the next couple of years. People who feel guilty about profiting from higher food prices simply have no understanding of basic economics. A proper speculator is a humanitarian in disguise. Why? By buying things when there’s a surplus, and prices are cheap, he’s in a position to make them available to the less prudent when there’s a shortage.Now’s an excellent time to speculate on these commodity type foods at these prices.Justin: Aside from plant-based meat, what other developments in the food industry should we expect? I recently read that insect-based foods might be needed to deal with overpopulation. What do you think?Doug: First of all, it’s too bad that most meat today is produced in an industrial manner. The conditions under which cattle, hogs, and chickens are produced are absolutely disgusting. The animals are full of steroids and antibiotics. And they’re often fed what amounts to cardboard. The entire process is very unaesthetic. I avoid industrial meat, milk, and eggs whenever possible. There’s a lot of truth to the saying “you are what you eat”, and nobody needs more steroids and antibiotics.But I’m not worried about the growing population. The population all over the world is actually dropping, particularly in North America, Europe, and Japan. And that’s not likely to change. It’s actually likely to accelerate. It’s even happening in China, the Middle East, and South America.The only place where population is growing is in Africa. Africans can’t feed themselves as it stands. They certainly won’t be able to if their population triples by the end of this century. Unless the continent completely reforms its political and economic systems, it’s in trouble. The whole continent is a welfare case, sucking capital out of the rest of the world.Contrary to most projections, however, I believe the population of Africa could collapse at some point – not for the reasons populations are declining in the developed world, but because they don’t produce anything. Africa doesn’t have the infrastructure, the capital base, or the political/economic environment to change that in the near term. The Central African Republic is much closer to reality than the country of Wakanda portrayed in the movie Black Panther. Anyway, they’re not competing with us for expensive foods like meat and fish. They’re competitors for subsistence foods.As for grubs and insects I’ve tried many of them when I was living in Thailand and Hong Kong. They can be very tasty. But, even there, they’re a specialty item. When they’re bred in meaningful quantities, however, they’ll be ground into mulch. Then they won’t be a delicacy for rich people, but subsistence protein for poor people. In any event, not a consideration for many years to come.Here’s the bottom line. It’s time to get long commodities.Justin: Great stuff. Thanks, Doug.Doug: You’re welcome.Justin’s note: As Doug said, now is a great time to bet on commodities.Our in-house commodities expert Dave Forest agrees. He says we’re entering the next “supercycle”… and smart investors stand to make a fortune.And just like Doug and I talked about today, he sees agriculture stocks specifically as one of the top ways to take advantage.The best part is, Dave just found the perfect way to profit. He just wrote about it in the latest issue of International Speculator, which subscribers can access here.If you’re not a subscriber, you can learn more, including another massive opportunity on Dave’s radar, by clicking here.last_img read more

FutureProof Your Career By Learning How to Code for Less Than 40

first_img 2019 Entrepreneur 360 List Add to Queue –shares Contributor Next Article Hone your programming skills on a shoestring budget with this nine-part training bundle. Apply Now » 4 min read Disclosure: Our goal is to feature products and services that we think you’ll find interesting and useful. If you purchase them, Entrepreneur may get a small share of the revenue from the sale from our commerce partners.center_img Future-Proof Your Career By Learning How to Code for Less Than $40 Entrepreneur Store Apple’s late founder Steve Jobs once said, “I think everybody in this country should learn how to program a computer because it teaches you how to think.” Today, a coding education does far more than that—it makes your future self employable.You think our world is computer-reliant now? Just wait a few years: Due to “greater emphasis on cloud computing, the collection and storage of big data, and information security”, the Bureau of Labor Statistics predicts that IT employment will grow 13 percent by the time 2026 rolls around—faster than the average for all occupations. And with 800 million jobs worldwide predicted to be under threat of automation by 2030, even further growth over the next decade would be hardly surprising.Learning how to code, then, is a surefire way to extend your career’s shelf life, and no program makes that task easier than the Complete Learn to Code Master Class Bundle. Comprised of nine different courses, it’s a beginner-friendly education in all things coding. Here’s what’s included: Basic Introduction To C++ For Beginners (a $199.99 value)Gain fluency in the C++ programming language across three hours of learning in this step-by-step, hands-on course. Designed to be learned at your own pace, it’ll show you how to write C++ programs from scratch so you have a solid foundation on which to develop your skills.Become A Full Stack Web Developer: Beginner To Advanced (a $199.99 value)Full-stack developers are the apples of the programming world’s eye, as they’re proficient in both front- and back-end development. Add this lucrative skill set to your roster with this project-packed course on full-stack dev tools and the PHP framework Laravel.Build Responsive Real World Websites with HTML5 and CSS3 (a $199.99 value)Learn how to build the responsive website of your dreams from scratch by enrolling in this 11-hour class on HTML5, CSS3, and jQuery. Its 77 lessons are enhanced with helpful video tutorials led by self-taught web designer and developer Jonas Schmedtmann.JavaScript Essentials: Get Started With Web Coding (a $199.99 value)Want to create interactive web content? You’ll need to know how to use JavaScript. This class is a great crash course in the programming language that’ll hone the skills you need in order to harness its capabilities for a fully functional and engaging site.C# 7 & .NET Core 2.0 Recipes (a $124 value)The multi-paradigm programming language C# (pronounced “C-sharp”) can be used to build a variety of applications on the .NET framework. Featuring five hours of content, this course will both introduce you to both tools and show you how to use their latest versions to create apps.The Complete Google Go Programming Course For Beginners (a $199.99 value)As the first development language designed specifically for modern multi-core CPU computers, Google Go has become ultra-popular in recent years. You’ll explore it in-depth when you enroll in this course, which features 51 lectures and five hours of content that’s available 24/7.From 0 to 1: Learn Python Programming Easy as Pie (a $49 value)The programming language Python is virtually ubiquitous, so you’d better learn how to use it, and use it well. This class will show you how to do just that with 10-plus hours of learning that covers data manipulation, machine learning implementation, text processing, website-scraping, and other uses of Python.Java Programming for Beginners (a $99 value)Speaking of must-know languages, meet Java. (It’s contributed to just about every web app or website, FYI.) This 50-lesson class is comprised of video lectures, lab exercises, and code examples that will give you a detailed understanding of Java programming.Git Complete: The Definitive, Step-By-Step Guide (a $99 value)Invaluable to software engineers, Git is a distributed version control system used to track and manage changes in computer files. After showing you how to install it on your Mac or Windows device, this course will demonstrate various Git commands and walk you through its uses in programming.A $1,370.95 value, lifetime access to the Complete Learn to Code Master Class Bundle is normally sold in the Entrepreneur Store for $79. Act fast, though, and you can score it for just $39 — a savings of 97 percent. Image credit: Danial RiCaRoS The only list that measures privately-held company performance across multiple dimensions—not just revenue. January 9, 2019 Programmerslast_img read more

FDA approves first noninsulin drug for treatment of pediatric patients with type

first_imgReviewed by James Ives, M.Psych. (Editor)Jun 18 2019The U.S. Food and Drug Administration today approved Victoza (liraglutide) injection for treatment of pediatric patients 10 years or older with type 2 diabetes. Victoza is the first non-insulin drug approved to treat type 2 diabetes in pediatric patients since metformin was approved for pediatric use in 2000. Victoza has been approved to treat adult patients with type 2 diabetes since 2010. Type 2 diabetes is the most common form of diabetes, occurring when the pancreas cannot make enough insulin to keep blood sugar at normal levels. Although type 2 diabetes primarily occurs in patients over the age of 45, the prevalence rate among younger patients has been rising dramatically over the past couple of decades. The Diabetes Report Card published by the U.S. Centers for Disease Control and Prevention estimates that more than 5,000 new cases of type 2 diabetes are diagnosed each year among U.S. youth younger than age 20.Victoza improves blood sugar levels by creating the same effects in the body as the glucagon-like peptide (GLP-1) receptor protein in the pancreas. GLP-1 is often found in insufficient levels in type 2 diabetes patients. Like GLP-1, Victoza slows digestion, prevents the liver from making too much glucose (a simple sugar), and helps the pancreas produce more insulin when needed. As noted on the label, Victoza is not a substitute for insulin and is not indicated for patients with type 1 diabetes or those with diabetic ketoacidosis, a condition associated with diabetes where the body breaks down fat too quickly because there is inadequate insulin or none at all. Victoza is also indicated to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease; however, its effect on major adverse cardiovascular events in pediatrics was not studied and it is not indicated for this use in children.Related StoriesStudy: Antidepressants reduce mortality by 35% in patients with diabetesNew biomaterial could encapsulate and protect implanted insulin-producing cellsSome people treated for type 1 diabetes may have monogenic diabetes, study findsThe efficacy and safety of Victoza for reducing blood sugar in patients with type 2 diabetes was studied in several placebo-controlled trials in adults and one placebo-controlled trial with 134 pediatric patients 10 years and older for more than 26 weeks. Approximately 64% of patients in the pediatric study had a reduction in their hemoglobin A1c (HbA1c) below 7% while on Victoza, compared to only 37% who achieved these results with the placebo. HbA1c is a blood test that is routinely performed to evaluate how well a patient’s diabetes is controlled, and a lower number indicates better control of the disease. These results occurred regardless of whether the patient also took insulin at the same time. Adult patients who took Victoza with insulin or other drugs that increase the amount of insulin the body makes (e.g., sulfonylurea) may have an increased risk of hypoglycemia (low blood sugar). Meanwhile, pediatric patients 10 years and older taking Victoza had a higher risk of hypoglycemia regardless of whether they took other therapies for diabetes.The prescribing information for Victoza includes a Boxed Warning to advise health care professionals and patients about the increased risk of thyroid C-cell tumors. For this reason, patients who have had, or have family members who have ever had medullary thyroid carcinoma (MTC) should not use Victoza, nor should patients who have an endocrine system condition called multiple endocrine neoplasia syndrome type 2 (MEN 2). In addition, people who have a prior serious hypersensitivity reaction to Victoza or any of the product components should not use Victoza. Victoza also carries warnings about pancreatitis, Victoza pen sharing, hypoglycemia when used in conjunction with certain other drugs known to cause hypoglycemia including insulin and sulfonylurea, renal impairment or kidney failure, hypersensitivity and acute gallbladder disease. The most common side effects are nausea, diarrhea, vomiting, decreased appetite, indigestion and constipation.The FDA granted this application Priority Review. The approval of Victoza was granted to Novo Nordisk. Source:U.S. Food and Drug Administration The FDA encourages drugs to be made available to the widest number of patients possible when there is evidence of safety and efficacy. Victoza has now been shown to improve blood sugar control in pediatric patients with type 2 diabetes. The expanded indication provides an additional treatment option at a time when an increasing number of children are being diagnosed with this disease.”Lisa Yanoff, M.D, acting director of the Division of Metabolism and Endocrinology Products in the FDA’s Center for Drug Evaluation and Researchlast_img read more

Novel noninvasive test for diagnosing gut diseases

first_imgThe usual strategy for diagnosing and monitoring IBD is based on a colonoscopy, which is invasive, often requires anesthesia, and assesses structural lesions, rather than gut malfunction. Gut disorders can happen before there are visible structural changes, so diagnosing based on functional tests evaluating gut leakage could allow clinicians to detect the disease earlier. While there is no cure for IBD, it is controllable. Early diagnosis would enable patients to control symptoms before they became severe, improving their quality of life.This new research provides a non-invasive, simple test that could not only be useful for diagnosing IBD, but also other gut disorders, such as celiac disease and food allergies. It’s also helpful for detecting diseases that result in a leaky gut, such as heart failure, high blood pressure and liver ailments.Marcin Ufnal, senior author on the study said: Reviewed by James Ives, M.Psych. (Editor)Jun 27 2019Gut diseases such as inflammatory bowel disease (IBD) are increasingly prevalent worldwide, especially in industrialized countries. In 2015 alone, 250,000 people in the UK were diagnosed with IBD, and 3 million in the United States. Symptoms can include pain and swelling of the stomach, bloody diarrhea, weight loss and extreme tiredness.A new study in Experimental Physiology proposes a novel, non-invasive test for assessing gut function that may help screen and monitor treatment of gut diseases using only a small sample (1 mL) of blood and stool. How well your gut functions is determined by the gut-blood barrier, a complex multi-layer system. This can be compared to a fine-tuned filter that precisely controls the passage of nutrients and prevents bacteria passing from inside the bowel into the bloodstream.Related StoriesResearch sheds light on sun-induced DNA damage and repairRaw meat can act as reservoir for bacteria associated with hospital infectionsNew methods to recognize antimicrobial resistant bacteria and how they workIn those with IBD, and other intestinal diseases, the gut-blood barrier is impaired. Here the intestinal wall is more like a ripped sieve, allowing more bacterial products to pass from the gut into the blood. This is commonly referred to as a leaky gut.This test measures the concentration of gut bacterial products (produced by bacteria during metabolism) in the patient’s blood and stool. The authors believe that with further research this assessment of gut leakage will be very important in the diagnosis and treatment of IBD and other intestinal diseases. (See related video for more on the science of leaky gut and the gut-to-blood permeability ratio). This may be a very important tool for diagnosis and treatment of gut and other diseases, using the leaky gut as a marker for disease, as well as a potential target for treatment. “center_img Source:The Physiological SocietyJournal reference:Jaworska, K. et al. (2019) Inflammatory bowel disease associates with increased gut-to-blood penetration of SCFA: a new, non-invasive marker of a functional intestinal lesion. Experimental Physiology. doi.org/10.1113/EP087773.last_img read more