a month agoAtletico Madrid coach Simeone: Juventus draw more than deserved

first_imgAbout the authorPaul VegasShare the loveHave your say Atletico Madrid coach Simeone: Juventus draw more than deservedby Paul Vegasa month agoSend to a friendShare the loveAtletico Madrid coach Diego Simeone insists they deserve their point with Juventus.This Champions League clash finished 2-2, after the Bianconeri were 2-0 up with Juan Cuadrado and Blaise Matuidi goals, but Atleti fought back with two headers from set plays courtesy of Stefan Savic and Hector Herrera.“We were missing something in the first half and Juve stepped up after the break, but I liked the fact we never gave in and fought back for a result,” said Cholo.“We always tried to create situations where we could hurt Juve. Jose Maria Gimenez went close, as did Vitolo and Angel Correa, so it was a more than deserved point.“I don’t see this draw as a good or bad result. Juve are very strong opponents with a lot of experience and an average age of 29 compared to our 24. Experience helps at this level and that is why matches like this can help us mature for what awaits in future.“The important thing is not to lose intensity during the game and to maintain faith in our characteristics.” last_img read more

We Looked At Almost 2000 Mock NFL Drafts Heres What We Learned

Metcalf became an overnight internet sensation during February’s combine with his comic-book physique and blazing 4.33-second 40-yard dash — a ridiculous amount of speed for a 228-pound man. He then turned right around and disappointed athletic measurable aficionados by posting a sluggish 7.38 seconds in the three-cone drill. Brown was not slow, running a 4.49 in the 40 at 226 pounds, but he appears to have stabilized at a level well below his teammate, and it’s unclear why. According to ESPN’s Stats & Information Group, Brown caught 1,320 receiving yards on 435 routes at Ole Miss in 2018, good for 3.03 yards per route run. Metcalf, hampered by injury, caught just 569 yards on 197 routes at 2.88 yards per route run, well under the efficiency set by Brown. Combine speed only weakly correlates to actual game speed, so it’s curious that a player like Metcalf would be selected over his more productive peer. Again, it might just be based on D.K.’s shirtless photo, suggesting this could be one the mock drafters get wrong. On Thursday, we’ll discover just how accurate these expert and amateur mock drafts are. If 2018 is any indication, mock drafters will probably correctly identify the majority of the players selected in the first round but completely whiff on the exact order and the actual team to select a player, which is probably for the best. Between last-minute trades and out-of-left-field picks, it’s more entertaining when we don’t know everything going in.From ABC News: Williams, a defensive tackle, finished eighth in the Heisman voting in 2018 and closed out the year at Alabama with 10 sacks and 55 pressures, according to Pro Football Focus. Williams also ranked first in the nation in run-stopping rate with 14.2 percent, showcasing his versatility. Meanwhile, Josh Allen (not to be confused with Bills QB Josh Allen, who can hit a goal post 50 yards away from his knees) creates pressure from the outside — pressure that Eric Eager and George Chahrouri of Pro Football Focus have shown to be more valuable in generating negative expected points for the opposing offense than interior pressure. Allen’s pass-rush productivity — the share of pass plays in which the defender applied pressure on the opposing QB — led the nation at 15.2 percent. The success of Rams interior lineman Aaron Donald seems to suggest that teams might hope for similar returns from Williams, but a sharp team will focus on creating as much outside pressure as possible by choosing Allen.The Iowa tight endsOne set of players moving up mock draft boards not only play the same position, but they were also college teammates. Tight ends Noah Fant and TJ Hockenson of Iowa are both mocked to go in the middle of the first round, and they’re also the only two TEs likely to be called in Round 1. But while Fant’s mock draft graph shows a flat overall trend, Hockenson’s draft stock has surged since the combine in February. On average, he’s now surpassed his Hawkeye cohort in projected draft position. The NFL draft is a spectacle. Last year, the draft averaged more viewers than the previous year’s Stanley Cup Final. Social media and fan interest have exploded with a thirst for draft information, and media outlets have sprung up to cater to those fans with a bevy of mock drafts conducted by analysts and armchair handicappers.There are even sites dedicated to tracking the predictions of mock drafters so that consumers of draft information can properly judge who is most reliable. Last year’s top forecaster, NFL analyst Evan Silva, identified 28 out of 32 players selected in the first round and also correctly predicted the team that would select 10 of those players. That 31 percent hit rate on pairing a drafted player with a team may not seem impressive, but it was good enough to place Silva at the top of the 2018 rankings and vault him to 16th over the past five years.“You should be able to pick 26 of the 32 first-round picks rolling out of bed,” Silva said. “The hard part is matching teams to players. I’m continually surprised each year. Teams don’t act like I expect.”Despite that uncertainty, the mock drafters can give us a pretty good sense of the names Roger Goodell will call on Thursday night. Perhaps even more interesting, we can use this data to explore the player trends as the draft process has progressed. The actual draft may be one weekend in April, but draft prognosticating is a year-round affair. Mock drafts from last June hardly resemble the ones on the eve of the draft, as the stock prices of college players are constantly ticking up and down based on a host of reasons — performance, health, eligibility and results from the scouting combine.Using data from Benjamin Robinson, who has curated close to 2,000 mock drafts from expert, media and fan sources from April 2018 to present, here are some of the most interesting fluctuations over the past few months — along with some of our own analysis mixed in. After all, it’s the draft, so we are all experts.The pass rushersPass rusher may be the position most stocked with top-end talent in this year’s draft. If Oklahoma QB Kyler Murray isn’t the first overall selection, Ohio State defensive end Nick Bosa will likely be called. But two other promising defensive standouts, Kentucky’s Josh Allen and Alabama’s Quinnen Williams, are expected to be off the board by the 10th pick. Both players wreaked havoc on the SEC in 2018, and the evolution of each player’s draft value has mirrored the other’s. While Bosa has been a fixture atop draft boards all year, Allen and Williams have each steadily climbed from a late first-round position. The mock drafters probably have the ordering right: Hockenson had 760 receiving yards — 25.8 percent of Iowa’s team total, according to ESPN’s Stats & Information Group — while Fant gained 519 yards for a 17.6 percent share. Hockenson is the better blocker of the two TEs and also ran 340 routes to Fant’s 242. But it wasn’t just volume that drove Hock’s numbers: He was also slightly more efficient on a per route basis, gaining 2.24 yards per route run vs. 2.14 for Fant. Hockensen was deployed further downfield than Fant as well, earning an average depth of target of 9.2 yards — nearly half a yard better than Fant. And despite the deeper routes, Hockenson still managed a higher catch rate.149 catches on 66 targets for Hockenson, 39 catches on 61 targets for Fant.The Ole Miss receiversOddly, another pair of teammates that play the same position are also vying for a first-round selection. The fortunes of Ole Miss wide receivers A.J Brown and D.K. Metcalf have flipped since the start of the draft process. Last July, A.J. Brown was considered a high first-round pick, but he has since seen his draft stack plummet to the bottom of the first round. read more

Ohio State cross country prepares for Big Ten Championship

After running against championship-level competition at the Wisconsin Adidas Invitational on Oct. 14, the Ohio State men’s and women’s cross country teams will run for a championship this Sunday in Illinois. The Buckeyes will run at the Big Ten Championship meet on Oct. 30 at the University of Illinois. Both the men and the women are hoping to finish in the top three of a field that features ranked teams on both sides. The No. 2-ranked Wisconsin Badgers and No. 7 Indiana Hoosiers highlight the men’s field while No. 15 Michigan State is the highest-ranked women’s team appearing. “I think Wisconsin and Indiana are probably a step ahead of the rest of the conference,” said Robert Gary, OSU men’s cross country head coach. “It’s not that they can’t be beat but they’re pretty solid. I think after that, we’re really fighting for third place.” OSU women’s assistant cross country coach Chris Neal said he felt similarly. “It’s going to be a hard-fought battle,” Neal said. “I think you could be winning it or you could be seventh. While our goal is top three I think we know it is going to be a tough weekend for us.” The men will be without one of their top runners, Jake Edwards, a redshirt senior. Edwards injured his hamstring at the Notre Dame Invitational on Sep. 30 and has not been able to compete since. Gary said that with Edwards out, the key to his team performing well will be running together as a pack. He said if his team can have a 20- to 25-second spread from its first to fifth runner, a third-place finish is possible. “I mean, obviously it would be a lot easier if Jake was running but someone else is just going to have to step up. We have a number of fifth-year seniors and I’m hoping they’re up to the challenge,” he said. Getting out fast at the beginning of the race is an important factor for the women, Neal said. “If we can put ourselves in good position and be where we want to be at the start, we’ll be able to hold it together for the last part of the race,” he said. Runners on both teams are confident and said they are ready to have their best races of the season. “I think everything is kind of coming together,” said Jordan Jennewine, OSU women’s redshirt senior. “I think we’re ready to run as well as we can this weekend.” Donny Roys, OSU men’s junior, feels the men’s team is also set to finish strongly. “I think we’re right on track to get into the top three. We’re stronger then last year so we’re getting out. I think we’re right on pace right now,” Roys said. After the Big Ten Championship meet, the men and women will have one week off from competition before running at the Great Lakes Regional meet on Nov. 12. read more

Mens Basketball CJ Jackson makes statement in Ohio States win over PurdueFort

Ohio State senior guard C.J. Jackson take a free throw in the second half of the Buckeyes’ game against Purdue-Fort Wayne. Ohio State won the game 107-61. Credit: Amal Saeed | Assistant Photo EditorThere have been talks about senior guard C.J. Jackson all throughout the summer.Jackson, who was No. 2 on Ohio State in points per game a season ago, has been seen as a leader for a team attempting to move on from the likes of Keita Bates-Diop and Jae’Sean Tate.On Sunday, Jackson proved his potential to be that guy.In the 107-61 victory against Purdue-Fort Wayne, Jackson had team highs with 25 points and five assists, while also finishing second on the team with six rebounds.The 25 points was also Jackson’s career high.Jackson said it was his teammates around him that allowed him to have the breakout performance.“My teammates just found me in the right spots tonight, and credit to them, just finding me and looking for me as I kind of got rolling a little bit,” Jackson said. “Once you see it finally go in, the confidence level goes up.”Though the Buckeyes ended up winning by 45, they only led by seven after the first half.The lead remained seven two minutes into the second half. That’s when Jackson took over.Already leading the team with 12 first-half points, the senior guard hit three three pointers within 66 seconds, all in succession for Ohio State, putting the team up 52-38 on his self-created 9-2 run.The Buckeyes outscored Purdue-Fort Wayne 55-23 from that point forward.Ohio State head coach Chris Holtmann said Jackson just took what the defense was giving him.“C.J. can get more happy with the three probably at times than I want him to, but they were going under a lot of ball screens today, and he’s worked on that part of his game,” Holtmann said.Jackson shot 72.2 percent on the day and made 4-of-7 from behind the arc. In the 2017-18 season, Jackson hit on 41.6 percent of his shots, and 37.9 percent of his three pointers.“The coaches stayed on me all summer, and that’s kind of where it started, right after the season ended we got straight to work,” Jackson said. “Once you get to this moment, it’s kind of like you’ve already been through it, so you just perform what you did all summer and all preseason.”Through two games, Ohio State has proven nothing about its style of play.The Buckeyes smothered Cincinnati defensively, holding them to less than 30 percent shooting and earning the low-scoring victory. On Saturday, they put up more than 100 points in the rout of the Mastodons. But in both games, it was Jackson who came up big when the team needed it.Though he only shot 3-for-10 against the Bearcats, one of those three baskets was a layup with 29 seconds remaining to put Ohio State up six. He then hit the last two free throws to officially seal the win.Against Purdue-Fort Wayne, Jackson played a complete game, looking like the best player on the court and finishing with the No. 2 plus-minus on the team.Holtmann said he liked what Jackson did on the defensive side as well, but that his team still has places to improve.Jackson said his performance only matters if it comes in an Ohio State victory.“As far as the win, that’s pretty much the only thing,” Jackson said. “We know we have to win to be successful, especially with the tough schedule that we have, so that’s kind of the only thing that I’m concerned with at this point.” read more

Rep Runestad hosts Milford police officer at state Capitol

first_img Categories: Runestad News,Runestad Photos 08Sep Rep. Runestad hosts Milford police officer at state Capitol Lt. Michael Lauridsen attends 9/11 Memorial Ceremony with lawmakerState Rep. Jim Runestad, R-White Lake, welcomed Lt. Michael Lauridsen of the Milford Police Department to the Michigan state Capitol for the annual 9/11 Memorial Ceremony hosted by the Michigan House of Representatives on Thursday. The ceremony, held on the House floor, marked the 15th anniversary of the Sept. 11, 2001 terrorist attacks on America, and also paid recognition by ringing a fire bell for each Michigan military member and first responder who lost their life in the line of duty over the past year.last_img read more

Asia Pacific pay TV growth over the next five year

first_imgAsia Pacific pay TV growth over the next five years will be robust but will likely be softer than previously thought because of Chinese cable subscribers cutting the cord in favour of OTT TV services, according to Digital TV Research.According to the research outfit, APAC pay TV subscribers will rise by 68 million over the next five years, with China and India together supplying two-thirds of the extra numbers, while revenues will increase by US$2.35 billion.China and India together will account for 80% of the region’s 681 million pay TV subscribers by 2024, meaning they will likely grow at a slower rate than the rest of the region.Growth will be led by IPTV platforms, with cable suffering from cord cutting. Digital cable subscriptions will be flat overall. China is forecast to lose 25 million cable subscribers between 2018 and 2024, although India will add 13 million. Analogue cable subscriptions will fall by 33 million.The pay satellite TV sector is mature, according to Digital TV Research, with only six million subscribers to be added between 2018 and 2024 to take the total to 89 million. Thanks to consolidation, India will lose nearly three million subscribers.Digital TV Research’s Asia Pacific Pay TV Forecasts report also predicted that Reliance is poised to shake up India’s fixed broadband sector with its Jio GigaFiber operation as it has done in the mobile sector, and that Indonesia, the region’s third most populous country, will enjoy substantial IPTV growth.Simon Murray, principal analyst at Digital TV Research, said: “IPTV is the biggest pay TV winner – adding 83 million subscribers between 2018 and 2024 to take its total to 272 million. Much of this growth will happen in China [up by 40 million] as cable subs convert to OTT or IPTV and in India [up by 28 million].”last_img read more

FutureProof Your Career By Learning How to Code for Less Than 40

first_img 2019 Entrepreneur 360 List Add to Queue –shares Contributor Next Article Hone your programming skills on a shoestring budget with this nine-part training bundle. Apply Now » 4 min read Disclosure: Our goal is to feature products and services that we think you’ll find interesting and useful. If you purchase them, Entrepreneur may get a small share of the revenue from the sale from our commerce partners.center_img Future-Proof Your Career By Learning How to Code for Less Than $40 Entrepreneur Store Apple’s late founder Steve Jobs once said, “I think everybody in this country should learn how to program a computer because it teaches you how to think.” Today, a coding education does far more than that—it makes your future self employable.You think our world is computer-reliant now? Just wait a few years: Due to “greater emphasis on cloud computing, the collection and storage of big data, and information security”, the Bureau of Labor Statistics predicts that IT employment will grow 13 percent by the time 2026 rolls around—faster than the average for all occupations. And with 800 million jobs worldwide predicted to be under threat of automation by 2030, even further growth over the next decade would be hardly surprising.Learning how to code, then, is a surefire way to extend your career’s shelf life, and no program makes that task easier than the Complete Learn to Code Master Class Bundle. Comprised of nine different courses, it’s a beginner-friendly education in all things coding. Here’s what’s included: Basic Introduction To C++ For Beginners (a $199.99 value)Gain fluency in the C++ programming language across three hours of learning in this step-by-step, hands-on course. Designed to be learned at your own pace, it’ll show you how to write C++ programs from scratch so you have a solid foundation on which to develop your skills.Become A Full Stack Web Developer: Beginner To Advanced (a $199.99 value)Full-stack developers are the apples of the programming world’s eye, as they’re proficient in both front- and back-end development. Add this lucrative skill set to your roster with this project-packed course on full-stack dev tools and the PHP framework Laravel.Build Responsive Real World Websites with HTML5 and CSS3 (a $199.99 value)Learn how to build the responsive website of your dreams from scratch by enrolling in this 11-hour class on HTML5, CSS3, and jQuery. Its 77 lessons are enhanced with helpful video tutorials led by self-taught web designer and developer Jonas Schmedtmann.JavaScript Essentials: Get Started With Web Coding (a $199.99 value)Want to create interactive web content? You’ll need to know how to use JavaScript. This class is a great crash course in the programming language that’ll hone the skills you need in order to harness its capabilities for a fully functional and engaging site.C# 7 & .NET Core 2.0 Recipes (a $124 value)The multi-paradigm programming language C# (pronounced “C-sharp”) can be used to build a variety of applications on the .NET framework. Featuring five hours of content, this course will both introduce you to both tools and show you how to use their latest versions to create apps.The Complete Google Go Programming Course For Beginners (a $199.99 value)As the first development language designed specifically for modern multi-core CPU computers, Google Go has become ultra-popular in recent years. You’ll explore it in-depth when you enroll in this course, which features 51 lectures and five hours of content that’s available 24/7.From 0 to 1: Learn Python Programming Easy as Pie (a $49 value)The programming language Python is virtually ubiquitous, so you’d better learn how to use it, and use it well. This class will show you how to do just that with 10-plus hours of learning that covers data manipulation, machine learning implementation, text processing, website-scraping, and other uses of Python.Java Programming for Beginners (a $99 value)Speaking of must-know languages, meet Java. (It’s contributed to just about every web app or website, FYI.) This 50-lesson class is comprised of video lectures, lab exercises, and code examples that will give you a detailed understanding of Java programming.Git Complete: The Definitive, Step-By-Step Guide (a $99 value)Invaluable to software engineers, Git is a distributed version control system used to track and manage changes in computer files. After showing you how to install it on your Mac or Windows device, this course will demonstrate various Git commands and walk you through its uses in programming.A $1,370.95 value, lifetime access to the Complete Learn to Code Master Class Bundle is normally sold in the Entrepreneur Store for $79. Act fast, though, and you can score it for just $39 — a savings of 97 percent. Image credit: Danial RiCaRoS The only list that measures privately-held company performance across multiple dimensions—not just revenue. January 9, 2019 Programmerslast_img read more

Research may pave way for development of potent weapons against cancer

first_imgReviewed by James Ives, M.Psych. (Editor)Nov 27 2018Despite significant advances in cancer research, the disease continues to exact a devastating toll. Because cancer is a disease of the body’s own cells, which mutate and develop under evolutionary pressure, conventional treatments like chemotherapy and radiation often leave behind a residue of resistant cells that go on to expand and wreak havoc.The best weapon against this implacable foe would be prevention, though to date, this has been an elusive goal.In a new study, Stephen Albert Johnston and his colleagues describe a method for pinpointing tumor-specific factors in blood that can elicit a protective immune response in the body and may one day be harnessed to produce an effective vaccine against the disease.The new study outlines a means for rapidly identifying peptides produced by tumor-associated mutations, then screening these peptides to find those exhibiting a strong immune response.A new visionThe work is part of a sea change in the field of oncology, where increasingly, the body’s immune system is induced to attack the disease. Immunotherapies have already shown startling effectiveness against certain previously intractable cancers and a pair of scientists were awarded this year’s Nobel Prize for their research into immune mechanisms known as checkpoint inhibitors.The technique described in the new study relies on libraries of peptides printed on slides known as peptide arrays. When such arrays are exposed to cancer-linked antigens in samples of patient blood, specific peptides bind with antibodies, suggesting they are recognized by the immune system and may be used in a vaccine against that cancer.Results of the study indicate that tumor-associated peptide mutations not only bind with immune antibodies, but can effectively provide cancer protection, (at least in animal models of the disease). The peptides generating a strong immune response could be incorporated into a vaccine or alternatively, used in conjunction with other forms of immunotherapy to treat existing cancers.Johnston and his colleagues used peptide arrays to screen for tumor-linked peptides in blood samples from dogs, examining responses to 9 different forms of cancer. The antigens showing the greatest immune response in the array were then evaluated for their protective effect against two forms of cancer, in a mouse model.The study confirmed that some of the peptides exhibiting a strong antibody response on the peptide arrays offered protection from cancer in mice, while non-immunogenic peptides did not.”Our system has the advantages of not requiring tumor tissue to DNA sequence and not having to guess whether a mutation elicits an immune response,” Johnston says.Johnston directs the Biodesign Institute Center for Innovations in Medicine. The new study appears in the journal Scientific Reports.Hidden in plain sightWhen viruses, bacteria or other pathogens attack the body, they often carry particular molecular signatures not present in normal cells. The immune system can recognize these foreign signatures, mounting a defense against the disease-causing invader.Cancer is different. Because cancer is a disease involving the body’s own native cells, most telltale signs of an alien presence, capable of triggering the immune system, are lacking.Fortunately, the body is not entirely defenseless against cancer. Certain signposts of illness produced by cancerous tumors can indeed provoke an immune response. Particular mutated peptides can act to alert the immune system, once they have been expressed, processed and presented on the cell surface, allowing the immune system warriors–the T cells–to recognize and attack the cancer.Identifying and harnessing these factors–known as neoantigens– is the focus of the new study.But while cancer produces a variety of mutations, whose traces may be registered by the immune system, Johnston notes that not all mutations are created equal. A specific form–known as frameshift mutations–have been shown to be more effective stimulators of immune response. They have been difficult to isolate and identify, until now.Related StoriesTrends in colonoscopy rates not aligned with increase in early onset colorectal cancerSugary drinks linked to cancer finds studyScripps CHAVD wins $129 million NIH grant to advance new HIV vaccine approachIf tumor-specific frameshift mutations can be recognized and applied in cancer therapy, the results are potentially dramatic, because T cells specific to cancer neoantigens can aggressively attack malignant cells without harming normal tissue.Shifting frames of referenceMost efforts toward a cancer vaccine have focused on so-called point mutations. Such mutations occur when a single DNA nucleotide letter is replaced with a different nucleotide. For example, an original sequence of ACCTACA could mutate to form a sequence reading ACCTATA.Point mutations therefore leave the sequence length unchanged, altering only the content of the DNA and resulting RNA transcripts. By contrast, frameshift mutations occur when sequence letters are inserted or deleted. (INDELS is the term for these insertion-deletion mutations.)Currently, use of point mutations for experimental cancer vaccines have been largely based on algorithms that make predictions about which neoantigens will yield an effective immune response, which can only be tested for effectiveness once the vaccine has been manufactured. The process, which is estimated to take 1-3 months, is cumbersome, very expensive and inaccurate. Use of frameshift peptide arrays could provide immediate information on peptide vaccine candidates and assess their immune reactivity before the formulation of vaccines.In addition to indels, frameshift mutations can occur through a process known as exon mis-splicing. Exon splicing occurs prior to translation from RNA to protein. Here, nucleotide sequences known as introns, which do not code for proteins, are cut from sequences and ends of the remaining coding regions, known as exons, are fused. This process can mis-splice–either omitting part of the exon or including part of the unwanted intron sequence. Like indel mutations, exon mis-splicing is a rich source of immunogenic mutations, explored in the current research.The searchThe new study describes a means of ferreting out tumor-specific peptides resulting from frame shift mutations by preparing peptide arrays containing libraries of frameshift peptides to probe for cancer-specific antibodies to them in dogs, then testing the capacity of the resulting antigens to protect against cancer in a mouse model.Dogs are subject to a variety of cancers that also plague humans, making them attractive subjects for such a study. Johnston plans to explore both therapeutic and prophylactic vaccines in dogs in parallel to human trials.As the authors note, there are a finite number of possible peptides displaying frameshift mutations, so it is possible to construct arrays capable of interrogating the entire sequence space of these mutations, eventually establishing the most immunogenic candidates. A group of 10-20 such frameshift peptides could be used for an anti-cancer vaccine.In the present study, 830 peptides from 377 predicted frameshift antigens were synthesized and affixed to array slides. 116 samples of blood serum from 26 dog breeds, representing 9 types of dog cancer (carcinoma, fibrosarcoma, hemangiosarcoma, lymphoma, mast cell tumor, osteosarcoma, histiocytic sarcoma, synovial cell sarcoma and malignant histiocytosis) were screened on the dog frameshift peptide array. 52 age-matched, blood samples from healthy dogs were used as control. (Each frameshift antigen was represented with 1-4, frameshift peptides, 17 nucleotides in length on the array.)Subsequent testing of the frameshift peptides demonstrated that reactive peptides provided T cell protection from melanoma and breast cancer in mice, whereas non-reactive peptides offered no such protection. Intriguingly, this tumor protection directly correlated to the degree of antibody response to frameshift peptides seen in the array results.The research paves the way for the development of potent new weapons against cancer, leveraging the body’s own immune defenses to stop this leading killer in its tracks.Source: https://biodesign.asu.edu/news/mutations-boost-immunity-toward-cancer-vaccinelast_img read more

Novel noninvasive test for diagnosing gut diseases

first_imgThe usual strategy for diagnosing and monitoring IBD is based on a colonoscopy, which is invasive, often requires anesthesia, and assesses structural lesions, rather than gut malfunction. Gut disorders can happen before there are visible structural changes, so diagnosing based on functional tests evaluating gut leakage could allow clinicians to detect the disease earlier. While there is no cure for IBD, it is controllable. Early diagnosis would enable patients to control symptoms before they became severe, improving their quality of life.This new research provides a non-invasive, simple test that could not only be useful for diagnosing IBD, but also other gut disorders, such as celiac disease and food allergies. It’s also helpful for detecting diseases that result in a leaky gut, such as heart failure, high blood pressure and liver ailments.Marcin Ufnal, senior author on the study said: Reviewed by James Ives, M.Psych. (Editor)Jun 27 2019Gut diseases such as inflammatory bowel disease (IBD) are increasingly prevalent worldwide, especially in industrialized countries. In 2015 alone, 250,000 people in the UK were diagnosed with IBD, and 3 million in the United States. Symptoms can include pain and swelling of the stomach, bloody diarrhea, weight loss and extreme tiredness.A new study in Experimental Physiology proposes a novel, non-invasive test for assessing gut function that may help screen and monitor treatment of gut diseases using only a small sample (1 mL) of blood and stool. How well your gut functions is determined by the gut-blood barrier, a complex multi-layer system. This can be compared to a fine-tuned filter that precisely controls the passage of nutrients and prevents bacteria passing from inside the bowel into the bloodstream.Related StoriesResearch sheds light on sun-induced DNA damage and repairRaw meat can act as reservoir for bacteria associated with hospital infectionsNew methods to recognize antimicrobial resistant bacteria and how they workIn those with IBD, and other intestinal diseases, the gut-blood barrier is impaired. Here the intestinal wall is more like a ripped sieve, allowing more bacterial products to pass from the gut into the blood. This is commonly referred to as a leaky gut.This test measures the concentration of gut bacterial products (produced by bacteria during metabolism) in the patient’s blood and stool. The authors believe that with further research this assessment of gut leakage will be very important in the diagnosis and treatment of IBD and other intestinal diseases. (See related video for more on the science of leaky gut and the gut-to-blood permeability ratio). This may be a very important tool for diagnosis and treatment of gut and other diseases, using the leaky gut as a marker for disease, as well as a potential target for treatment. “center_img Source:The Physiological SocietyJournal reference:Jaworska, K. et al. (2019) Inflammatory bowel disease associates with increased gut-to-blood penetration of SCFA: a new, non-invasive marker of a functional intestinal lesion. Experimental Physiology. doi.org/10.1113/EP087773.last_img read more

Twitter to be added to SP 500 index shares jump on news

first_img Twitter, whose shares are still trading more than 15% below where they were at the close of its first day of trading back on Nov. 7, 2013, will replace agriculture and chemicals maker Monsanto, which has been acquired by German giant Bayer, a deal that is expected to close soon.The announcement came from S&P Dow Jones Indexes after the close of trading last night.The tech company’s visibility has skyrocketed since President Trump entered the White House. He has used the digital communications platform to tweet messages on topics from trade and the economy, to the NFL’s kneeling controversy during the national anthem without any media filters.The stock, which is up nearly 58% so far in 2018 and has more than doubled in the past year, closed up 3.4% Monday at $37.88. Twitter’s market value was an estimated $28.5 billion heading into Tuesday’s trading session.Twitter’s entry into the S&P 500 sent its shares up more than 5% in early trading Tuesday to its highest level since March 2015.The reason? The stock’s inclusion in the S&P 500 means mutual funds and exchange-traded funds, or ETFs, that mimic and track the benchmark stock index must now buy Twitter shares to ensure they have the proper weighting in the stock.The S&P 500, a popular index that many money managers’ performance is compared against, is also viewed as the best gauge of the overall health of the stock market. There is more than $7.8 trillion benchmarked to the index, with index fund assets making up approximately $2.2 trillion of this total, according to S&P Dow Jones Indices.Twitter, which is headquartered in San Francisco, will be added to the broad “information technology” sector of the S&P 500, a move that boosts the index’s already sizable exposure to tech stocks.Tech stocks account for 26.2% of the closely watched index, which is weighted by market value, up from 20.8% at the start of the year, according to Bespoke Investment Group. The index’s current tech exposure is the highest since November 2000. The addition of Twitter means individual investors will own an even bigger chunk of technology.”We are keeping an eye” on the tech weighting, Justin Walters, co-founder at Bespoke, told USA TODAY. “These levels have only been seen once in history, and that was near the very peak of the dot-com bubble in 1999-2000.”Technology has been a market leader in 2018 as investors invest money in a part of the economy that is growing rapidly, innovating and could benefit from an expected increase in spending by businesses looking to expand their operations. The tech sector of the S&P 500 recently broke out to new all-time highs. Social media platform Twitter will be added to the S&P 500 stock index before the start of trading Thursday, a move that will expand the number of individual investors who own the stock through index funds that track the large-company stock gauge. ©2018 USA Today Distributed by Tribune Content Agency, LLC. Explore further Nasdaq OMX to rebalance index; Apple weighting cut Citation: Twitter to be added to S&P 500 index, shares jump on news (2018, June 6) retrieved 18 July 2019 from https://phys.org/news/2018-06-twitter-added-sp-index-news.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.last_img read more