Aims: To exploit the cyanobacterial diversity of microbial mats growing in the benthic environment of Antarctic lakes for the discovery of novel antibiotic and antitumour activities. Methods and results: In all, 51 Antarctic cyanobacteria isolated from benthic mats were cultivated in the laboratory by optimizing temperature, irradiance and mixing. Productivity was generally very low (<= 60 mg l(-1) d(-1)) with growth rates (mu) in the range of 0.02-0.44 d(-1). Growth rates were limited by photosensitivity, sensitivity to air bubbling, polysaccharide production or cell aggregation. Despite this, 126 extracts were prepared from 48 strains and screened for antimicrobial and cytotoxic activities. Seventeen cyanobacteria showed antimicrobial activity (against the Gram-positive Staphylococcus aureus, the filamentous fungus Aspergillus fumigatus or the yeast Cryptococcus neoformans), and 25 were cytotoxic. The bioactivities were not in accordance with the phylogenetic grouping, but rather strain-specific. One active strain was cultivated in a 10-l photobioreactor. Conclusions: Isolation and mass cultivation of Antarctic cyanobacteria and LC-MS (liquid chromatography/mass spectrometry) fractionation of extracts from a subset of those strains (hits) that exhibited relatively potent antibacterial and/or antifungal activities, evidenced a chemical novelty worthy of further investigation. Significance and impact of the study: Development of isolation, cultivation and screening methods for Antarctic cyanobacteria has led to the discovery of strains endowed with interesting antimicrobial and antitumour activities.
Home » News » COVID-19 news » Countrywide confirms phased branch reopenings and £60m cash in bank previous nextAgencies & PeopleCountrywide confirms phased branch reopenings and £60m cash in bankCompany says its priorities are to protect staff and customers but also conserve cash as it cautiously re-opens its business and accelerates use of virtual viewings.Nigel Lewis21st May 202002,540 Views Countrywide has confirmed that it has begun a phased re-opening of its business including branches and face-to-face valuation visits to properties, and that it has £60 million set aside to weather the crisis.The company has also confirmed that it is still in talks with HMRC to find out if it can access funds via the Coronavirus Large Business Interruption Loan Scheme to ‘improve its liquidity’.Countrywide has also revealed more details of how it is coping with the pandemic, including its continuing to rely heavily on web-chat and telephony to keep in contact with customers and that it has accelerated the roll out of virtual viewings. It is also now offering its customers online mortgage advice.“This way of working is resonating well with our colleagues and customers who are appreciative of this multi-channel choice of engagement, providing support and advice whilst allowing everyone to stay safe,” the company says.As we reported last week, Countrywide has taken a cautious approach to re-opening its business and has been busy undertaking a comprehensive risk assessment of its operations since the government announced the reopening of the property market on 12th May.“We continue to actively monitor the effect of the COVID-19 situation,” the company says.“The Board’s priority remains the safety of our colleagues and customers; to provide essential services to our customers; to preserve and protect the future of the business for our people; and to conserve cash and to manage the Group through the coronavirus pandemic.“Whilst the housing market in England was re-opened on 13 May, it is too early to assess the impact on housing transactions, and the Group is therefore unable to provide guidance on future profitability.”covid-19 coronavirus Countrywide May 21, 2020Nigel LewisWhat’s your opinion? Cancel replyYou must be logged in to post a comment.Please note: This is a site for professional discussion. Comments will carry your full name and company.This site uses Akismet to reduce spam. Learn how your comment data is processed.Related articles BREAKING: Evictions paperwork must now include ‘breathing space’ scheme details30th April 2021 City dwellers most satisfied with where they live30th April 2021 Hong Kong remains most expensive city to rent with London in 4th place30th April 2021
SIGN UP In a California split, Darragh Kenny (IRL) and Ben Maher (GBR) took home blue ribbons after topping a field of 121 entries in the $6,000 Bainbridge Companies 1.40m Jumpers as week three of competition got underway at the Winter Equestrian Festival (WEF) held at the Palm Beach International Equestrian Center (PBIEC) on Wednesday, January 27.Competition continues throughout the week as part of NetJets CSI3* show jumping with an action-packed schedule that features the Douglas Elliman Real Estate 1.45m Jumpers on Thursday, Friday’s $37,000 Adequan® WEF Challenge Cup Round 3, the CaptiveOne Advisors 1.50m Classic on Saturday, and the $137,000 NetJets Grand Prix CSI3* Sunday afternoon. Don’t miss a minute of the action and tune in the free livestream for all feature classes.Just seventh to go in the starting order, Kenny and Cicomein VDL, a 14-year-old Dutch Warmblood mare owned by HCK Collection, LLC, navigated all eight obstacles in the jump-off without fault for a double clear effort in a time of 36.036 seconds, quick enough to hold the lead right through to the finish.“I’ve had her in my string since the end of WEF last year,” said Kenny of the mare by Chacco-Blue x Jus de Pomme. “She’s super, super competitive, really careful, really easy, and I really enjoy riding her.”Kenny, currently ranked eighth in the world, is already off to a hot start at WEF jumping to an eighth-place finish in the $137,000 Restylane Grand Prix CSI3*. This week, he’ll have eight horses to campaign on the PBIEC grounds, making for another busy week of competition.“I’m very lucky. I have a great team of staff to help get the horses ready, so it makes my life a lot easier,” he said. “It’s always nice to have lots of horses to show because you don’t have to jump them too much or overuse them. You can just show them when you need to, and obviously with the schedule at WEF, it’s always good to have a lot of horses because you have a lot of great classes every single week with a lot of good prize money.”Over the course designed by Peter Grant (CAN) and Joey Rycroft (CAN), Maher and Jane Forbes Clark’s 10-year-old mare Ginger-Blue also put forth a double clear effort, stopping the timers at 37.329 seconds to capture the win in Section B.“It’s hard to build for these types of classes when there are over 100 riders in them, so I thought it was a good course,” said Maher, currently ranked sixth in the world rankings. “Personally, I use those classes to help produce the horses that aren’t quite ready to go to the FEI classes, so it was enough course, technical enough, but at the same time, they didn’t get too many clear rounds.”Like Kenny, Maher will be campaigning multiple horses this week and is coming off an exciting victory in Sunday’s $137,000 Restylane Grand Prix CSI3*. As a true horseman, Maher has adjusted his plan for WEF with the talented mare by Plot Blue x Royal Bravour, noting that her long-term development is his top priority.“I think she has a huge heart, and she’s very, very careful,” he said. “My initial plan setting out for WEF was to probably have her already jumping in one or two of the bigger FEI classes like the CSI3* Grand Prix classes, but I just feel that she needs a little bit more time to develop. I think I only competed on her twice the whole of last year, and I just feel like she’s lacking a little bit of experience. I want to take just a bit more time to produce her in the right way, so that when I’m ready to go for the bigger classes, that she’s been well enough educated and I don’t push her before she’s ready.”Final Results: $6,000 Bainbridge Companies 1.40m Jumpers Section A1. CICOMEIN VDL: 2007 KWPN mare by Chacco-Blue x Jus de PommeDARRAGH KENNY (IRL), HKC Collection LLC: 0/0/36.0362. NEWTON VAN HET KREKELHOF: 2013 BWP gelding by Diamant De Semilly x Hacienda D’eversemDANIEL DEUSSER (GER), Stephex Stables: 0/0/37.8343. SLIGO BALOU BOY: 2009 Irish Sport Horse gelding by Balou Du Rouet x CatianaBEN MAHER (GBR), Michael Kearins: 0/0/39.1244. BALOTELLI 5: 2010 Hanoverian gelding by Balou du Rouet x Contendro IMATTHEW BODDY (GBR), Purple Road, LLC: 0/0/39.7145. ENTANO: 2009 KWPN gelding by Namelus R x Numero UnoMEGAN MCDERMOTT (USA), Over the Top Stables LLC: 0/0/40.8706. RONJA: 2011 CH mare by Conteur x RangaERYNN BALLARD (CAN), Ilan Ferder: 0/4/37.850Final Results: $6,000 Bainbridge Companies 1.40m Jumpers Section B1. GINGER-BLUE: 2011 Dutch Warmblood mare by Plot Blue x Royal BravourBEN MAHER (GBR), Jane Forbes Clark: 0/0/37.3292. CALAFORNIA: 2007 KWPN gelding by Ultimo x LuxLAURA CHAPOT (USA), Laura & Mary Chapot: 0/0/38.8603. DIADEM DU THOT: 2013 SF gelding by L’arc De Triomphe*bois Margot x Olympe Du ThotLAURA KRAUT (USA), Stars and Stripes: 0/0/39.2364. LEONE JEI: 2012 KWPN gelding by Baltic Vdl x DaraMARTIN FUCHS (SUI), Adolfo Jui: 0/0/40.1525. LANGLEY HX: 2012 KWPN mare by Carambole x PetroescaALISE OKEN (USA), Hi Hopes Farm, LLC: 0/0/41.0816. CARDORA: 2006 Oldenburg mare by Cartogran x GrandoraTOMAS YOFRE (ARG), Paul Broder: 0/4/38.533 Tags: Darragh Kenny, Erynn Ballard, Ben Maher, PBIEC, show jumping, WEF Week 3, Ronja, Email* Subscribe to the Horse Sport newsletter and get an exclusive bonus digital edition! Horse Sport Enews We’ll send you our regular newsletter and include you in our monthly giveaways. PLUS, you’ll receive our exclusive Rider Fitness digital edition with 15 exercises for more effective riding. More from News:MARS Bromont CCI Announces Requirements For US-Based RidersThe first set of requirements to allow American athletes and support teams to enter Canada for the June 2-6 competition have been released.Canadian Eventer Jessica Phoenix Reaches the 100 CCI4*-S MarkPhoenix achieved the milestone while riding Pavarotti at the inaugural 2021 CCI4*-S at the Land Rover Kentucky Three-Day Event.Tribunal Satisfied That Kocher Made Prolonged Use of Electric SpursAs well as horse abuse, the US rider is found to have brought the sport into disrepute and committed criminal acts under Swiss law.Washington International Horse Show Returns to TryonTIEC will again provide the venue for the WIHS Oct. 26-31 with a full schedule of hunter, jumper and equitation classes.
View post tag: completes Back to overview,Home naval-today ConXtech Completes Structural Steel Erection at the Naval Base on North Island View post tag: North View post tag: Structural View post tag: Base February 11, 2011 View post tag: Erection ConXtech® Space Frame Systems has completed structural steel erection on a 152,000 gsf lodge for the US Navy at the Naval Base on North Isla…(prweb)[mappress]Source: prweb, February 11, 2011; Share this article View post tag: Naval View post tag: Island ConXtech Completes Structural Steel Erection at the Naval Base on North Island View post tag: Steel View post tag: ConXtech
A new study published by the University of Oxford suggests that the key to avoiding dementia may be a healthy heart. The study was funded by the Alzheimer’s Society. Its head of research, Dr Richard Oakley, said “Dementia devastates lives, and with the number of people with dementia set to rise to 1 million by 2025 and more families affected than ever before, reducing our risk has never been more important. This Alzheimer’s Society funded study didn’t look for a link between heart health and dementia directly, but it has shed important light on a connection between the health of our blood vessels and changes in the brain that indicate brain health. A joint investigation by Oxford University and University College London examined links between aortic stiffening and cognitive health. It concluded that faster stiffening of the aorta (the main artery carrying blood away from the heart) was linked to a lower blood supply to the brain, weaker connectivity between the regions of the brain, and memory loss. Individuals with pre-existing medical conditions such as heart disease, diabetes and high blood pressure are particularly vulnerable to aortic stiffening. However, lifestyle factors such as smoking can also play a role. The risks associated with stiffening arteries can be mitigated by a healthy diet and increased levels of exercise, as well as by medical treatments. “With no cure for dementia, there is an increased focus on understanding how to prevent or delay its onset. Importantly, our study helps us understand when in the lifespan it will be best to target and improve cardiovascular health to benefit the brain.” Dr Scott Chiesa, Research Associate at the UCL Institute of Cardiovascular Science, agreed with Dr Suri. The study involved 542 participants, whose aortic stiffness was measured at both 64 and 68 years of age. This was then compared to the results of MRI scans and cognitive tests. The researchers not only concluded that there was a link between the two, but also that making changes earlier in an individual’s life could help delay the effects of aortic stiffening, and so reduce the risk of diseases such as dementia later in life. “We know that what’s good for your heart is good for your head, and it’s exciting to see research that explores this link in more detail. But we need even more research to understand the impact of heart health on brain health as we age, and how that affects our own dementia risk. Alzheimer’s Society is committed to funding research into dementia prevention as well as research into a cure. But coronavirus has hit us hard, so it’s vital the Government honours its commitment to double dementia research spending to continue research like this.” Dr Sana Suri, the University of Oxford’s Alzheimers Society Research Fellow in the Department of Psychiatry, said “Our study links heart health with brain health, and gives us insights into the potential of reducing aortic stiffening to help maintain brain health in older ages. Reduced connectivity between different brain regions is an early marker of neurodegenerative diseases such as Alzheimer’s disease, and preventing these changes by reducing or slowing down the stiffening of our body’s large blood vessels may be one way to maintain brain health and memory as we grow older.” Image: sbtlneet / pixabay.com
Friday night’s “When Doves Cry: All-Star Prince Tribute” was a dance party of epic proportions. With incredible musicians coming together from all corners of the map to honor The Purple One, the music lasted deep into the night and provided a career-spanning set to a packed room in Brooklyn’s The Hall at MP. The All-Star Prince band came together in a heroic light, with Aron Magner (The Disco Biscuits), Marcus Rezak (Stratosphere All-Stars), Mike Greenfield (Lotus), and Louis Cato (Late Show With Stephen Colbert) holding ground. The horn section featured a powerful trio, with James Casey (Trey Anastasio Band) on saxophone, Maurice “Mobetta” Brown (Tedeschi Trucks Band, The Roots, Wyclef Jean & more) on trumpet, and Ian Gray (Swift Technique) on trombone. Con Brio’s Ziek McCarter, Mayteana Morales of The Pimps of Joytime, Hayley Jane of Hayley Jane and the Primates, and Nephrok of the Nephrok All-Stars shared earth-shattering vocals throughout the night, turning the room purple with a sense of wonderment. The band was hot, to say the very least.Watch this professionally shot video from the 1984 hit, “Let’s Go Crazy,” as produced by Sobokeh Exports:Thanks to photographers Dino Perrucci and Jay Sansone, you can relive some of the night through these incredible photos.Setlist: All-Star Prince Tribute at The Hall At MP, Brooklyn, NY – 5/6/16Set: I Wanna Be Your Lover, 1999, Raspberry Beret, Little Red Corvette, Cream, Let’s Go Crazy, DMSR, Lolita, Nothing Compares 2 You, A Love Bizarre, Kiss, Bambi, Purple Rain
Credit: Harvard’s Wyss InstituteCreated with microchip manufacturing methods, the organs-on-a-chip are cell-culture devices, each the size of a computer memory stick, that contain hollow channels lined by living cells and tissues that mimic organ-level physiology. These devices produce levels of tissue and organ functionality not possible with conventional culture systems, while permitting real-time analysis of biochemical, genetic, and metabolic activities within individual cells.The Wyss Institute team also has developed an instrument to automate the organs-on-chips and link them together by a flowing medium that mimics blood to create a human-body-on-chips and better replicate whole body-level responses. This automated platform could represent an important step toward more predictive and useful measurements of the efficacy and safety of potential new drugs, chemicals, and cosmetics, while reducing the need for traditional animal testing. Human organs-on-chips lined by patient-derived stem cells also could potentially provide a way to develop personalized therapies in the future.The technology’s rapid development, from demonstration of the first functional prototypes to multiple human organs-on-chips that can be integrated on a common instrument platform, also speaks to the institute’s ability to translate academic innovation into commercially valuable technologies in a big and meaningful way.“We took a game-changing advance in microengineering made in our academic lab, and in just a handful of years, turned it into a technology that is now poised to have a major impact on society. The Wyss Institute is the only place this could happen,” said Ingber, who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children’s Hospital, and professor of bioengineering at the Harvard School of Engineering and Applied Sciences.Since their 2010 publication in Science about the human breathing lung-on-a-chip, and with grant support from the Defense Advanced Research Projects Agency, the Food and Drug Administration, and the National Institutes of Health, Ingber and his team have developed more than 10 different organ-on-a-chip models, including chips that mimic liver, gut, kidney, and bone marrowThe transition of the organs-on-chips technology to a startup was enabled by the Wyss Institute’s technology-translation model, which takes leading high-value technologies that emerge from faculty efforts and “de-risks” them technically and commercially to increase the likelihood of their commercial success.The organs-on-chips project leaders included Ingber, Geraldine Hamilton, lead senior scientist on the biomimetics microsystems platform, and James Coon, an entrepreneur-in-residence at the institute. Hamilton and Coon will take senior leadership positions at Emulate, along with multiple members of the research team, smoothing the transition from academia to industry.“The organs-on-chips story is a great example of how the Wyss Institute brings researchers with industrial experience into the heart of our research community and effectively bridges academia and industry,” said Harvard Provost Alan M. Garber, chair of the Wyss Institute’s Board of Directors. In order to accelerate the development of new pharmaceuticals, Harvard’s Wyss Institute for Biologically Inspired Engineering announced that its human organs-on-chips technology will be commercialized by a newly formed private company.The announcement on Monday followed a worldwide license agreement between Harvard’s Office of Technology Development (OTD) and the startup Emulate Inc. The agreement, relating to the use of the institute’s automated human organs-on-chips platform, includes not only pharmaceuticals, but chemical, cosmetic, and personalized medicine products as well.“This is a big win towards achieving our institute’s mission of transforming medicine and the environment by developing breakthrough technologies and facilitating their translation from the benchtop to the marketplace,” said Wyss Institute Director Donald Ingber, who led the organs-on-chips effort.
November marked the close of Library Lab, one of the Harvard Library’s more inventive programs from recent years. Participants and supporters from across the University recently came together to celebrate their accomplishments.The project drew together Harvard’s technologists and humanists with the mandate to experiment, build and test out their ideas aimed at improving library services for students and faculty, and to bring the successful projects to the world via open-source code.Among the various projects implemented are Awesome Box, which allows users to promote any items during a simple choice in the return location, and Inscriptio, which allows carrel users to request and make reservations in an approach similar to that of airline seating.“We created stuff. We built a community. We’re wrapping up,” Sue Kriegsman, program manager, succinctly said. Scroll down to read more on the program outcome and celebratory event.
McGlinn Hall was named the 2018-2019 Hall of the Year, the first time it has been named Hall of the Year since its establishment in 1997. Sophomore and dorm vice president Isabella Schmitz said McGlinn has come a long way in recent years.“When I first arrived at ND I think they had gotten like last place in all of the Hall of the Year stuff, but then last year we got most improved, and this year we won it all,” Schmitz said.Junior and former dorm president Colleen Ballantyne said this year McGlinn made an effort to reach outside the dorm by planning events with Keough Hall and Lyons Hall, their brother and sister dorms.“Last year was a lot of building our community more internally after a year where our hall council didn’t do as much to really build that community,” Ballantyne said. “This past year we were able to focus on letting the McGlinn community shine throughout campus and even sometimes off campus.”McGlinn’s signature event, Casino Night, was also incredibly successful this year, Schmitz said.“Our event coordinator got all the McGlinn girls really excited about making it as best as it could be,” Schmitz said. “She set a goal for us and said we need to make more money than we ever have, and people were excited by that.”Ballantyne said the dorm broke its record by raising $3,150 for St. Adalbert Catholic School in South Bend. McGlinn sends students to tutor at the school every weekday.Rector Sister Mary Lynch said the dorm’s relationship with St. Adalbert began during the first few years in her job as rector of McGlinn, a position she took on in 2005.“I wanted someplace in South Bend where the students could actually go and be there and help and do service,” Lynch said.McGlinn sought to improve their dorm’s sustainability this year through a partnership with the Office of Sustainability and TerraCycle, an organization that collects non-recyclable waste and partners with corporate donors to turn it into raw material to be used in new products.“We’ve only been doing it for about two months now, but we’ve been able to collect a ton of stuff that otherwise would’ve been going to the landfills,” Ballantyne said. “We’re hoping to work with the Office of Sustainability to branch this out throughout campus in the near future.”McGlinn also prides itself on their interhall sports participation. The hall has held the Kelly Cup since 2010-2011, which Ballantyne said is largely due to the hall’s unofficial official motto: McGlinn never forfeits. The Kelly Cup is for the overall women’s interhall sports championship, and is awarded based off of interhall participation and performance.“My thing is that, first of all, interhall sports are to help relieve stress, so I don’t want any stress in trying to win the Kelly Cup,” Lynch said. The second thing is, I always tell them, if we say we’re gonna put a team on the field, we put a team out, so no forfeiting.”An unexpected event this year that brought the McGlinn community together was Lynch’s cancer diagnosis in the fall.“I think the way the women here responded and rallied around me, and how we were still able to continue all the programs hall government and hall council had planned — things went along pretty much as normal — was one of the main reasons for winning Hall of the Year,” Lynch said.The dorm organized a spreadsheet where people could sign up to bring Lynch dinner from the dining hall as she could not eat there among so many people.“The spreadsheet would fill up within an hour—it would be completely full,” Ballantyne said. “And it was like not the same girls every month — it was different people all the time.”The dorm also made fanny packs to show their support of their rector.“I had slow drip cancer treatment that I wore a fanny pack for 48 hours every other week,” Lynch said.Lynch discovered that her chemo pack was able to fit in the McGlinn fanny pack and was able to use it instead of the oncologist issued one.When Lynch was declared cancer free, the dorm surprised her with a party and a video containing messages from former students and former Residential Assistants of McGlinn, as well as messages from Fr. Jenkins and Muffet McGraw, Schmitz said.“I just have been absolutely amazed at the women here this year,” Lynch said. “If good can come out of a tough situation, I think that’s what happened. Just the spirit and the sense of community that evolved this year more so than some other years — and I don’t know if it was the rallying around me and my situation or what — but the women have just been amazing, absolutely amazing.”Tags: Community, dorm features, dorm life, Hall of the year, McGlinn Hall
In the first nine months of this year, the total revenues of the Adris Group amounted to HRK 4,7 billion, which is 12 percent more than the revenues generated in the same period last year. Revenues from the sale of goods and services amount to 4,1 billion kuna and are 20 percent higher than last year. Net profit amounts to HRK 752 million, which is a growth of 20 percent.Compared to the same period last year, Maistra achieved four percent more overnight stays, with an increase in the average price of overnight stays of three percent, which led to an increase in operating revenues of 10 percent. EBITDA (profit before depreciation, interest and taxes) amounts to HRK 540 million and is 10 percent higher than last year. EBIT (profit before interest and taxes) recorded a growth of nine percent and amounted to HRK 407 million. The realized net profit of HRK 359 million represents an increase of 12 percent compared to the first nine months of last year. Current booking confirms the current positive revenue growth trends. The completion of the Park Hotel, a key product in the process of completing the top hotel offer in Rovinj, is underway.”Adris is operating successfully. Our businesses are growing and sustainable in the long run. We do not reduce ambitions, we invest. In the past eight years, we have invested seven billion kuna, increased competitiveness, exported. We are extremely focused on organic growth and business excellence, ready for new acquisitions as well“Said the President of the Management Board of the Adris Group, M.Sc. Ante Vlahović.The process of business integration of the company HUP into the tourist part of the Group is in progressPhoto: MaistraThis year’s acquisition of the Adris Group, HUP Zagreb, is a company that significantly contributes to the strengthening of the tourism part of the Group and which also achieves the growth of all key business indicators. These indicators, in addition to Zagreb hotels, also include the operations of Dubrovnik hotels within the Hotels Dubrovnik Riviera branch.Compared to the same period last year, HUP realized nine percent more overnight stays, with an increase in the average price of overnight stays of five percent. Operating revenues are higher by 13 percent, and EBITDA is 145 million kuna and 14 percent higher than last year. EBIT recorded a growth of 24 percent and amounted to HRK 113 million. The realized net profit in the amount of HRK 96 million is 25 percent higher.The process of business integration of the company HUP into the tourist part of the Group is in progress. The aim of the project is to establish a unique model of tourism management in order to continue long-term sustainable growth. Today, the tourist part of the Adris Group has 83 percent of hotel capacity at the level of four and five stars. In addition to a quality portfolio and operational excellence, the foundation of sustainability is positioning in three growing and internationally recognized destinations – Rovinj, Dubrovnik and Zagreb.Related news:ADRIS GROUP ANNUAL REPORT EXCEEDED AGAIN WITH CREATIVE SOLUTION – TESTED FOR CHALLENGES